There are three main forms of estrogen in the body:
1) Estrone E1
2) Estradiol E2
3) Estriol E3
Some of the differences are estrone, E1 for short, is the one estrogen that remains in the body even after menopause and is often the one thought to be responsible for the female related cancers such as breast cancer, because it unopposed by other hormones to help provide the healthy balance, that is meant to be.
EstradioI is nicknamed E2 and that is the predominant hormone that we use to help abate some of those symptoms such as hot flashes, night sweats, mood swings, etc.
Estriol, E3 is called the third or sometimes even called a weak estrogen because it actually helps balance the estrogen activity in the body by almost being an anti-estrogen estrogen and really helps promote that balance.
Dr. Erica Oberg, physician and researched joins Elevate Your Energy to talk about epigenetics and nutrigenomics. Are you confused by genetic SNPs and what they mean? What is MTHFR? Is there a link between MTHFR and other genetic mutations?
Dr. Oberg will also invite you to participate in a research study so we can learn more about the impact of treating some of these mutations. To be a part of this, you can contact firstname.lastname@example.org.
If you've been doing some of your own research into MTHFR, Dr. Oberg will discuss where to find a practitioner who can help you.
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"I just cannot believe that methylfolate & methylcobalamin took away all the symptoms I had for 6 years"
This is just one out of many other incredible, life changing testimonials captured in a recently published study in the Journal of Clinical & Medical Genomics on patient and provider experiences with MTHFR polymorphisms and methylfolate.
Be amazed. Read for yourself the incredible life changing patient stories.
Want to participate in the next research study? We are currently seeking patients getting methylfolate and /or methylcobalamin injectable or sublingual for the first time as prescribed by their doctors. Participation is online and easy. You can make a different in medicine and change lives.
It's one thing to eat healthy at mealtimes, but snacking healthfully can be just as important. The best snack for you is the one that tastes good and keeps you feeling energized between meals, such as:
Handful of nuts: Nuts are full of healthy fats and protein, which help stabilize blood sugar levels. To satisfy salt cravings, try tamari almonds instead of pre-salted blends.
Veggies and dip: Carrots, celery, broccoli, tomato, cucumber and cauliflower are just a few of veggies you can dip. For healthy dips, try hummus, guacamole, baba ghanoush or bean dip.
Apple with almond butter: Salty and sweet, this combo is a winner. The fiber of the apple and the protein of the almond butter help you to feel full and energized.
Yogurt and berries: Live yogurt has probiotics that help keep your gut healthy. Berries add sweetness along with nutrients that support your blood vessels’ health.
Helpful tips provided by Bastyr Clinic
The potential impact of estrogen on a woman’s health and wellbeing is enormous. While much attention has been given to the subject of hormone replacement, there has been very little discussion regarding the importance of estrogen metabolism, that is, how estrogen is broken down in the body. There is a growing body of evidence that shows it is not simply the total amount of estrogen in the body but how estrogen is metabolized that may play an important role in disease development. Regardless of the source; a woman’s own natural estrogen, hormone replacement, or xenoestrogens in the environment, how estrogen is broken down can be of critical importance in conditions such as cancer, heart disease, osteoporosis, and autoimmune disorders.
Estrogen is metabolized in the body along two major pathways and one minor. In one of the major pathways, estrogen is metabolized into 16 alpha-hydroxyestrone. This metabolite exerts a powerful stimulatory effect on target tissues, including the breast. Levels of 16 alpha-hydroxyestrone may increase in response to obesity, alcohol or toxic exposure. High levels of this potent metabolite are suggested to have significant estrogenic effects and may be associated with higher rates of breast cancer. The minor pathway for estrogen metabolism is 4-hydroxyestrone which may also enhance cancer development.
The other major pathway is 2-hydroxyestrone which breaks down estrogen into a much weaker metabolite with less stimulatory effects on target tissues. Therefore, if you metabolize estrogen primarily through the 2-hydroxyestrone pathway you may lower your risk of cellular damage and cancer.
A proper balance between 2-hydroxyestrone and 16 alpha-hydroxyestrone is critical to lowering the risk for estrogen dependent health problems.
So, what can you do to optimize estrogen metabolism?
Moderate exercise, flaxseed, soy, kudzu, cruciferous vegetables (broccoli, cauliflower, brussels sprouts), and omega 3 fatty acids can all help to increase metabolism through the” good” or 2-hydroxyestrone pathway. The supplement, indole-3-carbinol, can also raise your good estrogen metabolite levels.
Have your doctor measure your urinary metabolites of 2-hydroxy and 16 alpha-hydroxyestrone. This assessment can be done in both premenopausal and postmenopausal women. Testing can assess the need for dietary and lifestyle changes as well as assess the impact of hormone replacement therapy.
By Dr. Linda Olafson, M.D., FAAFP from North Coast Integrative Medicine.